THE MICROSCOPIC changes in otosclerosis are well known, although several questions, particularly those concerning the onset of the pathologic changes, remain unanswered. The etiology of otosclerosis, however, is a problem; neither examinations of human temporal bones nor experimental work has succeeded in solving it. For this reason the classification of otosclerosis as a pathologic entity is likewise problematic, and investigations which may eventually shed light on the etiology and the pathologic type of otosclerosis are of interest. An investigation of this sort is based on the question of whether systemic disorders, metabolic or endocrine in origin, or pathologic changes in the entire capsule of the labyrinth exert an influence on the progress of otosclerosis. Some work on the subject is available. For example, Mayer1 examined a temporal bone presenting an association of otosclerosis and osteitis deformans. I examined a temporal bone in a case of otosclerosis associated with ochronosis.
BRUNNER H. OTOSCLEROSIS ASSOCIATED WITH OSTEOPOROSIS AND LABYRINTHITIS CHRONICA OSSIFICANS. Arch Otolaryngol. 1949;49(2):184–195. doi:10.1001/archotol.1949.03760080062005
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: