EXPERIMENTAL means of producing bone changes in the otic capsule are limited. One method that has recently been brought into focus is concerned with vitamin A depletion of young animals.
According to Wolbach,1 vitamin A is one important factor that is specifically concerned with the growth of the bony skeleton of mammals. The peculiar growth sequences in epiphysial cartilage are arrested in animals depleted of vitamin A. Remodeling of bones of cartilaginous origin in the base of the skull is arrested also. The growth of the calvaria, of membranous origin, which normally increases in area and changes in curvature by resorption in the exterior of the skull and deposition of bone on the interior surface, is also affected. These processes are accelerated but maintain the same pattern with excessive vitamin A feeding, according to Wolbach. Mellanby,2 however, expressed the belief that normally this development of skull and vertebrae takes place
PERLMAN HB. EFFECT ON THE EAR OF VITAMIN A FEEDING AFTER SEVERE DEPLETION. Arch Otolaryngol. 1949;50(1):20–35. doi:10.1001/archotol.1949.00700010027003
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