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This is a work from the department of ophthalmology of the University of Geneva, Switzerland. The introductory chapter deals with the role of exogenous factors (application of roentgen rays to the mother's pelvis or to the father's testis, administration of estrogens, use of contraceptive agents, lead poisoning) in the production of congenital malformations, particularly during the first ten weeks of pregnancy. It also deals with various infections (cocci, bacilli, viruses) occurring in the mother.
Toxoplasmosis, recently studied by Wolf and Cowen, a specific granulomatous inflammatory process (encephalitis, chorioretinitis) produced by a crescentic protozoan, when transmitted from mother to infant may, according to the author, take three forms: acute, subacute (with encephalitic symptoms: convulsions, stupor, areflexia, amblyopia, hydrocephalus) and chronic (latent). Laboratory studies of the spinal fluid show albuminocytologic dissociation, and roentgenograms reveal intracerebral calcifications (not specific). Funduscopy shows characteristic bilateral central macular and perimacular chorioditis and areas of atrophy surrounded
Répercussions sur l'enfant des maladies infectieuses de la mère pendant la grossesse (toxoplasmose et embryopathie rubéoleuse en particulier): Etude clinique, encéphalographique et sérologique. Arch Otolaryngol. 1949;50(3):369–370. doi:10.1001/archotol.1949.00700010379016
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