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November 1949

MÉNIÈRE'S SYNDROME: II. The Cochlear Disturbance

Arch Otolaryngol. 1949;50(5):564-588. doi:10.1001/archotol.1949.00700010578004

THE FIRST PART of this communication was concerned with the acute phase of Ménière's syndrome—the vestibular disturbance or attacks of vertigo.1 The second part deals with the cochlear disturbance—the deafness and tinnitus—which persists between the acute attacks, or the chronic phase.

In considering the acute phase it was pointed out that clinical observations of 87 consecutive patients with Ménière's syndrome showed them to have signs of chronic vitamin deficiency, often of severe degree; that the two groups into which patients with this syndrome have so far been divided by means of the histamine skin test present different predominating deficiencies, the histamine-negative group showing a predominant niacin deficiency and the histamine-positive group a predominant riboflavin deficiency; that the type of vertigo experienced by the two groups is not the same, and, finally, that there must now be recognized a third group giving an intermediate response to histamine intradermally and showing

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