THE USE of sulfamylon® and streptomycin in local treatment of otitis media with or without acute exacerbation seems to be a valuable addition to the armamentarium of the otolaryngologist. As will be shown, the use of this combination has dramatic results in clearing some types of infections, but in others, especially external otitis, it has no effect.
Sulfamylon,® a sulfanilimide derivative, has a chemical formula of SO2NH2.C6H4.CH2NH2.HCL, and a chemical name is 4-(aminomethyl)-benzene sulfonamide hydrochloride. It has a molecular weight of 222.67 and a melting point of 260 to 265 C. (corrected). It is a white crystalline material, soluble in water to 50 Gm. per hundred cubic centimeters at 25 C. and is weakly acid in reaction. Experimentally, this drug is excreted rapidly from the kidneys in three to four hours in the form of a heavy precipitate
DIEHL KL, MORRIS AG. SULFAMYLON® AND STREPTOMYCIN IN TREATMENT OF INFECTIONS OF THE EAR: A Preliminary Report. Arch Otolaryngol. 1949;50(6):700–707. doi:10.1001/archotol.1949.00700010715003
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