THE DESIGNATION vitamin P was given in 1936 by Szent-Györgyi and his Hungarian co-workers to a substance or group of substances, other than ascorbic acid, which were present in extracts of paprika and lemon peel. The letter "P" was chosen because the preparation appeared to restore to normal abnormally increased permeability of capillaries.1 The crystalline extract obtained from lemons was termed "citrin." This extract was believed to contain two different flavone dyes, hesperidin and eriodictyol glucoside, and was said to decrease the number of hemorrhages in scorbutic guinea pigs and to prolong their survival time. Clinical application indicated that the increased capillary permeability associated with nonthrombopenic purpura and infections was corrected by oral administration.2 Early attempts3 to confirm the results obtained in animals were unsuccessful, but later several investigators were able to show that vitamin P does affect capillary resistance.4 It was found also that certain
SAYLOR BW. TREATMENT OF ALLERGIC AND VASOMOTOR RHINITIS WITH HESPERIDIN CHALCONE SODIUM. Arch Otolaryngol. 1949;50(6):813–820. doi:https://doi.org/10.1001/archotol.1949.00700010828014
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