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Article
February 1950

CRANIAL CHORDOMA

Arch Otolaryngol. 1950;51(2):237-244. doi:10.1001/archotol.1950.00700020258009
Abstract

CHORDOMA is a fairly rare tumor derived from notochordal remnants, which are found along the craniosacrococcygeal axis. It is locally malignant. Most frequently it is found originating in the sacrum or cranium.1 Its consideration in differential diagnosis of intracranial and nasopharyngeal tumors is sufficient reason to report a new case together with a brief outline of the nature of the tumor and the disease.

EMBRYOLOGY  A proper understanding of the nature of the tumor necessitates a brief discussion of the embryology of the notochord.2The notochord has as its anlage a rodlike mesodermal structure, growing forward from a knob of cells at the head end of the primitive streak. This is a thickened band of ectoderm, which occupies the midplane of the embryonic disk. The latter is present at the end of the second week and is the result of the apposition of the floor of the early amnion sac

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