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February 1950


Author Affiliations

From the Eye, Ear, Nose and Throat Section, Veterans Administration Hospital (Kennedy), Medical Teaching Group.

Arch Otolaryngol. 1950;51(2):258-262. doi:10.1001/archotol.1950.00700020279011

Plasma cell tumors occur chiefly in the following locations: first, in the skeleton, particularly in the medullary portion of the long bones, being usually multiple and a variety of multiple myeloma; and, second, in the upper respiratory tract, where they are more commonly solitary and considered as an extramedullary type which tend to invade adjacent structures by continuity. Nothing more need be stated about the skeletal type except that such myelomas are defined as tumors arising in bone marrow. The cause of solitary plasmocytomas in the upper respiratory tract and their relation to multiple myeloma are not definitely known except that they resemble each other histologically.

Histologically, a plasmocytoma is composed chiefly of plasma cells. These cells are probably specific, differentiated lymphocytes. The cells vary in size, are elliptical and contain an eccentric nucleus. The nuclear chromatin has a spokelike arrangement. The cytoplasm is basophilic, and there is a pale

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