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March 1950


Arch Otolaryngol. 1950;51(3):335-343. doi:10.1001/archotol.1950.00700020357005

FOR THE past two years, in our services at the Philadelphia General, the Episcopal, the Pennsylvania and the Abington Memorial hospital, we have been observing a group of patients with laryngeal tuberculosis. These patients, 37 in all, were given 0.5 Gm. of streptomycin intramuscularly, twice a day, during periods varying from two weeks to six months, for an average of three months per patient.

The dose of 1 Gm. per day was used because all the available literature indicates that this amount can be used safely over a long period. The patients were studied by means of frequent clinical observations, caloric tests and whispered voice tests after which, audiograms were made when considered necessary and a series of moving pictures of the larynx taken in color by one of us (W. A. L.).

In a review of the literature 1 on the use of streptomycin for pulmonary tuberculosis, it was

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