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Article
March 1950

MELKERSSON'S SYNDROME

Author Affiliations

DANVILLE, VA.

Arch Otolaryngol. 1950;51(3):371-377. doi:10.1001/archotol.1950.00700020393008
Abstract

IN 1928 Melkersson1 described an unusual syndrome consisting of recurrent peripheral facial paralysis associated with chronic edema of the face and lips. Inasmuch as the cause and the pathologic changes in this puzzling condition remain uncertain, the experience with an additional case is deemed worthy of reporting.

According to Kettel,2 Melkersson's syndrome is recognized at the present time as a triad of findings: (a) peripheral facial paralysis, (b) chronic angioneurotic facial edema and (c) lingua plicata. The peripheral facial paralysis in this syndrome is indistinguishable from Bell's palsy. The angioneurotic edema is chronic and is most often localized to the lips, usually the upper lip. The deeply furrowed tongue, or lingua plicata, was added to the syndrome by Rosenthal3 in 1931.

Kettel has pointed out that the disease frequently begins in childhood or youth, in the majority of cases before the eighteenth year. Swelling of the face may occur at

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