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March 1950


Arch Otolaryngol. 1950;51(3):451-460. doi:10.1001/archotol.1950.00700020473017

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Factors Influencing the Growth of Lymphoid Tissue.Dr. Abraham White, Philadelphia (by invitation).  The data presented are based on animal experimentation, for the most part, from which three factors influencing the growth of lymphatic tissue are discussed. These factors are endocrine, dietary and those of stimuli arising from without. Injection of adrenotropic hormones of the anterior lobe of the pituitary gland results in involution of the thymus and the lymphatic nodes. After removal of the adrenal glands, lymphoid tissues hypertrophy. Experiments on dogs have shown that the tonsils follow the same course. Histologic examination shows shrinkage of the lymphocytes with ultimate dissolution. Secretion of the adrenotropic hormone of the pituitary gland is stimulated by various factors, such as toxins, bacteria and temperature changes. Doses of roentgen rays up to a certain point stimulate adrenocortical secretion, whereas larger doses, beyond this point, cause involution. Changes due to the sex hormones are most

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