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June 1950


Arch Otolaryngol. 1950;51(6):917-924. doi:10.1001/archotol.1950.00700020943011

WITH the advent of the sulfonamides and, later, of penicillin and streptomycin, thrombosis of the cavernous sinus has passed from the list of unsolvable otolaryngologic problems. This condition has been considered an otolaryngologic problem for the reason that the causes of thrombosis of the cavernous sinus are chiefly diseases of the nose and ear and therefore come within the dominion of the otorhinlogist.

The first case was found at autopsy and reported by Duncan in 1821.2 The first clinical report of the condition was made by Vigla in 1839.3 Bircher4 in 1893 reported the first case with recovery following surgical procedure. Grove5 in 1936, after reviewing all the cases reported up to that date, stated that in the acute fulminating type of thrombosis or thrombophlebitis of the cavernous sinus the mortality rate was almost 100 per cent and that in all the other types the rate was 93