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Article
July 1950

USE OF AUREOMYCIN IN EXTERNAL OTITISComparison with Other Drugs Now in Use

Arch Otolaryngol. 1950;52(1):74-81. doi:10.1001/archotol.1950.00700030093010
Abstract

EXTERNAL otitis is an annoying and ubiquitous condition. The diagnosis can be perplexing, but the trained otologist should make few mistakes. Therapy, however, has always been attended by frequent failures and recurrences. Recently much has been added to the knowledge of this subject. Senturia,1 Quayle2 and others have shown that the condition is a bacterial and not a fungus infection and that acute external otitis and chronic suppurative external otitis are caused primarily by gram-negative bacteria, particularly Pseudomonas aeruginosa. Since these monumental papers were published, there has been a redirecting of investigational work on this subject, resulting in the introduction of many new drugs which have increased the incidence of cures in external otitis. Quayle2 advised use of 10 per cent sulfadiazine ointment with methylrosaniline chloride. Reardon3 advised coparaffinate (iso-par® ointment). Spence4 used 10 per cent sulfanilamide ointment. Hayes and Hall5 used an entirely new drug, dibromosalicylaldehyde (dalyde®). Senturia

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