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August 1950

IV. Clinical Observations

Author Affiliations

From the Department of Bacteriology and Division of Oto-Laryngological Diseases, Duke Hospital.

Arch Otolaryngol. 1950;52(2):220-224. doi:10.1001/archotol.1950.00700030241011

THE PROGRESS made in recent years in the field of allergy and immunology has provided an explanation for certain human ailments, for example, rheumatic fever, glomerulonephritis, serum sickness and periarteritis nodosa. Dammin and Bukantz1 stated:

It has generally been accepted that the development of host hypersensitiveness... is the essential pathogenetic basis for the subsequent morphologic alterations characteristic of these diseases and that the lesions observed result from the union of the responsible antigen with its antibody in the tissues of the sensitized host.

Since man is penetrated every day by micro-organisms that "do not leave a record worthy of medical attention,"2 he may nevertheless build antibodies to many of these organisms. Otomycosis also may belong to this type of disease process, since a person may become sensitized to an air-borne fungus. Constitutional and genetic factors, however, may determine which person will become hypersensitive to any particular micro-organism. Lamson

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