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August 1950

STREPTOMYCIN IN TREATMENT OF SCLEROMA: Report of Three Cases with Successful Results

Author Affiliations

From the Department of Otorhinolaryngology, State Hospital, Zagreb.

Arch Otolaryngol. 1950;52(2):253-256. doi:10.1001/archotol.1950.00700030274014

EVERY specialist is aware of the resistance of scleroma to any form of therapy. Many methods of treatment—from use of various vaccines to surgical, roentgen and radium therapy—have been tried. In cases with laryngeal and tracheal scleroma lesions, attempts were made to remove new-formed tissue by diathermic coagulation through a tracheostomy opening. However, none of these methods could ever produce a definite cure. It is characteristic of the disease that it recurs at extremely irregular intervals, and symptoms may appear after a long interval, either at the previous site after treatment or in some other part of the respiratory tract. As a rule, the therapies so far applied have succeeded only in restricting the evolutive activity of the disease and thus mitigating its symptoms.

Since scleroma is endemic in Yugoslavia, its incidence is fairly high. There are families with two or three members who have the disease, and probably there

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