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Article
October 1950

N-BUTANOL: ITS USE IN CONTROL OF POSTOPERATIVE PAIN IN OTORHINOLARYNGOLOGICAL SURGERY

AMA Arch Otolaryngol. 1950;52(4):549-564. doi:10.1001/archotol.1950.00700030573004
Abstract

PAIN has always constituted a major problem confronting the medical profession, and methods for its satisfactory control have been explored by innumerable research and clinical investigators. The otorhinolaryngological surgeon is constantly aware of this problem in patients with various diseases in the head, neck and chest, as well as in patients after many different operative procedures. He is therefore interested in any field of research from which he can obtain assistance in his efforts to alleviate pain.

The purpose of this investigation was to determine the clinical significance of a new concept regarding the pathogenesis of pain in operative wounds and to determine the relief from pain obtainable through the therapeutic application of certain aspects of this concept. For this purpose, a study was made of the relief from pain obtained in several large groups of patients from the surgical wards of the ear, nose and throat service and the

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