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Article
March 1951

ACTION OF DIMENHYDRINATE (DRAMAMINE) AND OTHER DRUGS ON VESTIBULAR FUNCTION

Author Affiliations

NEW YORK
From the Department of Therapeutics, New York University-Bellevue Medical Center, and the Ear, Nose and Throat Services of Lenox Hill and Bellevue Hospitals.

AMA Arch Otolaryngol. 1951;53(3):308-315. doi:10.1001/archotol.1951.03750030067008
Abstract

DIMENHYDRINATE (2-[benzohydryloxy]-N, N-dimethylethylamine 8-chlorotheophyllinate) (dramamine) has recently been introduced for the prevention and treatment of motion sickness. It has been employed successfully in seasickness1 and airsickness.2 Several reports have appeared attesting to its value in radiation sickness,3 nausea and vomiting of pregnancy,4 Ménière's syndrome,5 vestibular reactions following labyrinthine operations6 and in vertigo of vestibular origin.7 Although the drug by weight contains 54 per cent of diphenhydramine and 46 per cent of 8-chlorotheophylline, it is considered to be a specific chemical compound rather than a mixture of its two components (fig. 1).

METHOD  The action of dimenhydrinate on vestibular function was investigated by means of the cold microcaloric test8 and galvanic stimulation of the mastoid area.9 The former method depends on the integrity of the peripheral end organ in the labyrinth. By means of 2 cc. of ice water (water with floating

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