IN COLLOIDS the diffusion of the dispersed substance, produced by the brownian movement, is retarded by the influence of gravitation, which induces sedimentation of the particles; the larger the particles, the greater is the influence of gravitation. The aerosols used in therapy of the upper respiratory passages are composed of particles of large diameter, often exceeding 1 micron; thus, their sedimentation will differ according to the plane considered, the upper or the lower horizontal plane. In the administration of aerosolized antibiotics, according to the method of Barach,1 into certain cavities, such as the sinuses, with a poorly vascularized surface that does not easily lend itself to a good redistribution of the deposited substance, it is interesting to show this asymmetry of the sedimentation, to estimate it approximately and, in conclusion, to find a means of improving this condition. Following is a description of the experiments made toward this end.
LADOUCE PD. SEDIMENTATION OF AEROSOLS IN THE INTERIOR OF THE SINUSES. AMA Arch Otolaryngol. 1951;53(3):316–318. doi:10.1001/archotol.1951.03750030075009
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