IN THE Archives of December 1949, Hasegawa1 discusses his work with experimental animals and man for the prevention of motion sickness. He states that this sickness is due, above all, to abnormal stimulus of the otolithic apparatus, which expresses itself through the vagosympathetic system. To confirm this affirmation, he reminds the reader that the signs of motion sickness are lacking in animals whose otolithic crystals have been destroyed through centrifugation or in animals in which a sympathectomy has been performed. Since animals deprived of their otoliths do not show evident disturbances in balance, Hasegawa believes that destroying otoliths in man may be the best method of preventing motion sickness.
Granted that men evidently cannot undergo centrifugation, he searched for a method of practical operation that would destroy the otolithic crystals in order to make the disturbances they produce disappear.
He states that he found sodium bicarbonate, injected intravenously, to
GIACCAI F, CARLE A. OBSERVATIONS ABOUT THE PRESUMED ACTION OF SODIUM BICARBONATE ON THE OTOLITHIC CRYSTALS. AMA Arch Otolaryngol. 1951;53(4):434–438. doi:10.1001/archotol.1951.03750040083009
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