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August 1951


AMA Arch Otolaryngol. 1951;54(2):200. doi:10.1001/archotol.1951.03750080088016

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In March, 1950, I presented a review of the laboratory and clinical results obtained with corticotrophin and cortisone to the otolaryngological service of the New York City Hospital. On the basis of these findings speculations were made as to the possibility of inhibiting osteogenesis during the fenestration operation.

The fenestration operation for clinical otosclerosis has often been accompanied with many disappointments. The natural forces which tend toward osteogenetic repair have stimulated the efforts of physicians in various directions in an attempt to overcome this great barrier to complete success. I believe that since all technical efforts have in the long run been ineffective in inhibiting osteogenesis, a new biological orientation should be sought.

The relatively short experience with corticotrophin and cortisone has already furnished rather impressive evidence as to their effect on osteogenetic metabolism. The inhibiting of osteogenetic and mesenchymal elements by corticotrophin without interference with epithelial proliferation may be

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