STREPTOKINASE and streptodornase offer the surgeon a new biologic approach to the therapy of infections. Fibrin and desoxyribose nucleoprotein form substantial parts of the solid increment of thick pus. If thick viscid purulent material could be successfully removed from infected areas, the formation of healthy granulation tissue and consequently healing could be facilitated. Through their catalytic and enzymatic properties, streptokinase and streptodornase produce the hydrolysis of fibrin and desoxyribose nucleoprotein if direct contact can be effected for a sufficient period of time. Thick purulent material is thus made less viscid and therefore more easily aspirated, with the result that infected areas can be cleaned up preparatory to plastic surgery. Clinical experience with these compounds in the treatment of infections has been uniformly good. Streptokinase and streptodornase have wide clinical applications. They will prove useful wherever the surgeon wishes to cleanse the wound of fibrin and desoxyribose nucleoprotein. Their usefulness is
MILLER JM, LONG PH. TREATMENT OF ANTRO-ORAL FISTULA WITH PARTICULAR REFERENCE TO USE OF STREPTOKINASE AND STREPTODORNASE. AMA Arch Otolaryngol. 1952;55(4):453–455. doi:10.1001/archotol.1952.00710010465008
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