SEVERAL while patients were being treated with cortisone and corticotropin (ACTH) for various diseases of mesenchymal tissues.1 These clinical observations led to investigations to determine the effect of these hormones on the healing of experimental wounds. It was shown that when standard skin defects were made in rabbit ears the effect of cortisone caused a delay in the growth of all elements of connective tissue2 and retarded the growth of granulation tissue in open wounds.3 When experimental fractures were made in rabbits, gross healing of the fractures and absorption of the hematomas were greatly delayed in the animals receiving cortisone.4 Additional studies on the effect of cortisone on induced open wounds in mice5 as well as incised wounds in rabbits 6 have also shown an inhibitory effect on wound healing. In man the effect of corticotropin on the healing of wounds in two patients was
RAMBO JHT. EFFECT OF CORTISONE ON OSTEOGENESIS FOLLOWING FENESTRATION IN THE MONKEY: An Experimental Study. AMA Arch Otolaryngol. 1952;55(5):554–558. doi:10.1001/archotol.1952.00710010568005
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