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October 1952

TREATMENT OF TUBERCULOSIS OF LARYNX: Comparative Study of Streptomycin, Paraaminosalicylic Acid, and Tibione

Author Affiliations

From the Otolaryngologic Service of Sea View Hospital, Staten Island, and the Otolaryngologic Service of the University of the State of New York, College of Medicine, New York; services of Dr. J. G. Gilbert.

AMA Arch Otolaryngol. 1952;56(4):435-447. doi:10.1001/archotol.1952.00710020457011

STREPTOMYCIN has been used long enough to allow a proper evaluation of this antibiotic in the treatment of laryngeal tuberculosis. Paraaminosalicylic acid and tibione (4-acetylaminobenzaldehyde thiosemicarbasone) have been used for a shorter period. Nevertheless, certain conclusions regarding these newer chemotherapeutic agents can also be drawn at this stage.

This is a survey of 136 cases of tuberculosis of the larynx in which streptomycin was used; 21 cases in which paraaminosalicylic acid was used, and 20 cases in which tibione was used. The streptomycin therapy was started in April, 1947, the paraaminosalicylic acid therapy in September, 1949, and the tibione therapy in December, 1949. The first 20 cases in the streptomycin group were reported in a previous communication.1 The follow-up since that publication has modified some of our original conclusions.2

In any study of a new therapeutic agent, controls are of paramount importance. In this study we have had

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