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Article
February 1953

NONEXPERIMENTAL NASAL AND PARANASAL PATHOLOGY IN HEREDITARILY OBESE MICE

AMA Arch Otolaryngol. 1953;57(2):143-151. doi:10.1001/archotol.1953.00710030162003
Abstract

OVERWEIGHT is found, according to Jolliffe,1 to be present in 28% of the people of the United States. Data for Massachusetts gathered by Ryder and Getting2 in a health protection clinic showed that excess weight was more frequent by far than any other pathological condition discovered in their institute.

With these facts in mind animal experimentation, long used to gain insight into the origin of this condition, was greatly promoted after the discovery was made that obesity could be produced in normal animals by bilateral lesions of the hypothalamus.

After a high incidence of overweight was observed in persons with sinus complaints (Kelemen3), it was thought to be of interest to examine the nasal cavities of animals with experimentally created obesity. Dr. John Brobeck, of the Department of Physiology, Yale University Medical School, collaborated by releasing heads of rats which became obese after appropriate surgical intervention. Although

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