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Article
August 1953

SINUSITIS AS FOCUS OF INFECTION IN UVEITIS, KERATITIS, AND RETROBULBAR NEURITIS

AMA Arch Otolaryngol. 1953;58(2):154-165. doi:10.1001/archotol.1953.00710040173005
Abstract

THE THEORETICAL basis for the focus of infection theory involves one or more of the following assumptions in the etiological relationship to secondary disease:

  1. Toxemia.

    • Lymphangitis with or without:

    • Bacteremia.

  2. Bacterial allergy.

  3. Reflex relationships.

  4. In the case of the sinuses, direct extension of infection to contiguous structures.

There are many weaknesses in the theory, as clinicians have learned from practical experience.1 Some mentioned are:

  1. Assigning to the focus an etiological role in any disease that happens to coexist in the patient.

  2. "Disproving" by statistics of any importance of foci by showing:

    • The presence of such foci in large groups of people otherwise in essentially normal health.

    • The highly frequent absence of cure of the supposedly secondary disease in large groups when the focus is removed.

    • The use of single-case observations to reason from the particular to the

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