THIS PAPER is being presented as a thorough ear, nose, and throat survey on 100 persons who were picked at random from a chromate plant in eastern Ohio. The study was carried out at the Cleveland Clinic Foundation under the auspices of Dr. T. F. Mancuso, Department of Industrial Hygiene, Ohio State Board of Health.
Cummings1 first described "chrome holes" in 1827. Hamilton2 says that Becourt and Chevalier in 1851 described a new skin disease due to chrome without apparent knowledge of Cummings' paper.In 1854 Heathcote3 described an obstinate ulceration of the tonsils and pharynx in a bichromate-factory worker. Legge in 19024 stated that no such extensive ulceration had been observed since. However, Wutzdorff5 noted slight ulceration of the gums and pharynx.Legge was the first to write a complete description, including pathology and order of occurrence of symptoms, of the effects of
MILLER JB. EFFECT OF CHROMATES ON NOSE, THROAT, AND EAR. AMA Arch Otolaryngol. 1953;58(2):172–178. doi:10.1001/archotol.1953.00710040191008
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