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September 1953

VERTIGO: A Therapeutic Approach Based upon Its Physiopathological Aspect

AMA Arch Otolaryngol. 1953;58(3):273-300. doi:10.1001/archotol.1953.00710040293004

IN OCTOBER, 1950, I presented the results of an investigation of the use of n-butyl alcohol (n-butanol) in the control of postoperative pain in otorhinolaryngological surgery.1 The results of this investigation confirmed the findings of Revici concerning the beneficial effect of n-butyl alcohol on traumatic pain.2 In that communication, I presented an outline and summary of Revici's hypothesis regarding the physiopathological aspects of pain.

According to this hypothesis, an initial distinction must be made between physiological pain, a sensation induced by an excitation acting upon normal tissue, and pathological pain, resulting from abnormal metabolic processes in the pathological tissue. An analysis3 of pathological pain permitted further recognition of two different patterns in the abnormal metabolic processes of abnormal tissues, one causing the appearance of acid substances and the other of alkaline substances. Two types of pain have been recognized, one related to a local