THE IMPORTANCE of cultivatable micro-organisms currently considered as secondary invaders and of the different strains of virus currently considered as primary in the causation of influenza and other epidemic respiratory infections is still a largely unsolved problem. The investigations on influenza virus have yielded information of the greatest importance as regards its presence and nature. The results of virus neutralization tests with convalescent serum for the identification of different strains in epidemics are reminiscent of the early studies on identification of different types of pneumococci by serologic means. At first there was but one type of the Pneumococcus and one strain of influenza virus and then two, three, and so on. The uncertainty as to presence of virus and the type at hand in current epidemic outbreaks, the changes that occur in influenza virus during epidemics, the difficulty and delay entailed in the identification of virus strains, the toxicity and
ROSENOW EC. DIAGNOSTIC CUTANEOUS REACTIONS, SPECIFIC PREVENTION AND TREATMENT IN EPIDEMIC RESPIRATORY INFECTIONS. AMA Arch Otolaryngol. 1953;58(5):609–622. doi:10.1001/archotol.1953.00710040635009
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