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THE HIGH mortality rate of malignant neoplasms of the sinuses furnished the stimulus for the following study and preliminary report of 91 cases followed at the University Hospital, Ann Arbor, Mich., from 1932 to 1948. More recent cases are not included, because the outcome of many is still in doubt. Emphasis is placed on diagnosis, because it is here that much valuable time is lost before definitive therapy is begun. For this reason a large group of neoplasms involving the sinuses which are secondary to an obvious primary neoplasm of the skin are omitted. However, those which may have been primary in the alveolus are included.
There were 78 patients from 22 to 85 years of age and averaging 57 years of age who presented themselves with carcinoma. These varied from a well-differentiated medullary carcinoma, Grade I, arising in a papilloma, to highly anaplastic growths classified only as poorly differentiated