IN OTORHINOLARYNGOLOGY there are scarcely any disorders so refractory to therapy as ozena, chronic atrophic rhinitis, and rhinopharyngitis sicca. Innumerable attempts have been made to treat these conditions, ranging from use of purely systemic to local treatment and even to extensive operative intervention.
As early as 1927 Glasscheib1 advanced the opinion that ozena was due to avitaminosis A, while in 1929 Fleischmann2 considered the curative component to be vitamin D contained in cod-liver oil. In 1947 Scuderi3 reported that he had successfully treated patients with vitamins A and D (Alfadol).
At the Scandinavian Congress of Otology in Oslo, in 1950, I reported on ozena treated with vitamin A. The paper was published in Acta oto laryngologica, Supplement 95, and will be summarized briefly below.
For years I have treated rhinitis and pharyngitis sicca as well as ozena with vitamin A. For many years the patients received small
STRANDBYGARD E. TREATMENT OF OZENA AND RHINOPHARYNGITIS CHRONICA SICCA WITH VITAMIN A. AMA Arch Otolaryngol. 1954;59(4):485–491. doi:10.1001/archotol.1954.00710050497007
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