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Article
April 1954

CHLORAMPHENICOL (CHLOROMYCETIN) IN TREATMENT OF AURAL INFECTIONS

AMA Arch Otolaryngol. 1954;59(4):499-502. doi:10.1001/archotol.1954.00710050511009
Abstract

A RECENT report has indicated that chloramphenicol (Chloromycetin) used locally is of value in the treatment of infected ears.1 Ears draining because of many causes (acute and chronic external otitis, otitis media with central and marginal perforations of the tympanic membrane, and postoperative mastoid cavities) were treated with a 1.5% solution of chloramphenicol. The primary diluent of the drug was acetyl dimethylamine, secondarily diluted with 70% alcohol. The use of this drug resulted in cessation of drainage in 78% of the ears so treated.

Many other drugs have been similarly locally used for relief of drainage in diseased ears. Among these can be mentioned nitrofurazone (Furacin),* dihydrostreptomycin-boric acid powder,5 a sulfanilimide derivative (Sulfamylon),† streptomycin,8 Sulfamylon and streptomycin,9 and polymyxin-bacitracin.10 Peele2 refers to over 50 articles on various medications (not all different) used in treating draining ears, including many of those previously noted.

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