RECENT experiments have proved that a convulsant dose of pentylenetetrazole (Metrazol; Cardiazol) can increase the permeability of the encephalon to procaine, whereas such increase is not to be noticed after electric shock.1 We thought that it would be interesting to see whether a convulsive state artificially excited could alter the blood-encephalic barrier and, along with it, the other three great barriers, which supervise the interchange between blood and aqueous humor, blood and liquor (spinal fluid), and blood and labyrinthine fluids, respectively.
Ample studies have been made concerning each one of these barriers in order to determine, by means of well-characterized and easily measurable substances, the relationship between the structure of these substances or, better, their chemical and physical properties and their capacity for crossing the various barriers.2 Likewise, we wanted to see which alterations, both in the universal and in the strictly regional conditions of the organism, could
FREGNI R, DE POLI A. CONVULSIVE STATE PRODUCED BY VARIOUS TYPES OF SHOCKConduct of Three Barriers (Blood-Aqueous, Blood-Labyrinthine Fluids, and Blood-Liquor [Spinal Fluid]) with Reference to Some Convulsive States. AMA Arch Otolaryngol. 1954;60(2):149–153. doi:10.1001/archotol.1954.00720010155004
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