ANATOMY, PHYSIOLOGY, PATHOLOGY, DIAGNOSIS
RICHTER1 studied serial sections of the nose in 12 embryos from the second month on and 25 autopsy specimens from early childhood, for the purpose of determining the rate of development and distribution of the mucous glands. In general he found that the glands developed pari passu with the mucous membrane as it grew from without inward to line the newly forming cavities. Thus, in the very young fetus the glands are first seen low down in the vestibule, and as the epithelial carpet spreads inward and upward, glands develop in the same direction. For instance, in the middle of the fourth fetal month he found budding glands in three locations, namely, the middle meatus, on the septum just above the recess of Jacobson's organ, and in the vestibule just beyond the mucocutaneous junction. Since the sphenoid sinus appears early, he found evidence of developing
SALINGER S. THE PARANASAL SINUSES. AMA Arch Otolaryngol. 1954;60(2):203–240. doi:10.1001/archotol.1954.00720010209012
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