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Article
October 1954

EOSINOPHILIC GRANULOMA OF THE FRONTAL BONE: Report of a Case

Author Affiliations

PHILADELPHIA

AMA Arch Otolaryngol. 1954;60(4):501-504. doi:10.1001/archotol.1954.00720010513014
Abstract

EOSINOPHILIC granuloma is primarily a disease of the reticuloendothelial system and is related to Hand-Schüller-Christian disease and Letterer-Siwe disease. In fact, Jaffe. who reported one of the first cases bearing this name, believes that these conditions are clinical gradations of the same basic disorder. It is thought at present that eosinophilic granuloma is infectious in nature, although no specific organism has been discovered.

This granuloma usually occurs in children and affects any of the bones, especially those of the skull, ribs, and ilium.

The onset is insidious, and usually the pathology is discovered accidentally by x-ray (by physical signs of enlargement over the bone affected or precipitation by trauma). Clinically the disease is manifested by a nontender enlargement or swelling over the area involved. Since it is osteolytic, x-rays show areas of well-circumscribed radiolucencies. Microscopically, clumps of eosinophiles are predominant. A large amount of plasma cells, reticular network, leucocytes, lymphocytes,

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