RHINOSCLEROMA is relatively rare in this country but is being reported with increasing frequency in recent years. Of approximately 120 cases reported in the United States and Canada, about 25 have occurred in native-born persons, the rest in foreign-born.1 The disease almost always begins in the nose with a dry mucous membrane and crusting. This stage may last for years but gradually passes into a second stage of fungating granulomas. The disease may spread to the pharynx and larynx. In the third stage the granulomas become hard and sclerotic and then leave scars and stenoses.
The diagnosis can be established by biopsy and by culture of the von Frisch bacillus, Klebsiella rhinoscleromatis. There has been much discussion in the past as to whether the von Frisch bacillus was the true etiologic agent, and the evidence accumulated to date indicates that it is the cause of the disease.2
FOLBRE TW, MANHOFF L, FRAZIER DW. RHINOSCLEROMA SUCCESSFULLY TREATED WITH OXYTETRACYCLINE (TERRAMYCIN). AMA Arch Otolaryngol. 1954;60(4):505–507. doi:10.1001/archotol.1954.00720010517015
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