THE PRESENT study was done in 1948, after the successful treatment of a 48-year-old patient with severe acute mastoiditis, who showed a remarkable improvement from this treatment without mastoidectomy.The main purpose of the intra-arterial injection is the sudden attack of the pathological tissues by means of a high concentration of penicillin. The observations were clinically made on 24 patients with acute mastoiditis. Very detailed observations were carried out on 10 of these patients. In addition, 20 rabbits were used in experimentation. The observations made fall into six main categories: (1) measurements of sensitivity to penicillin of the bacteria which caused the acute otitis media; (2) measurements of the distribution of penicillin in the ear discharge and in the blood of the internal jugular vein on the diseased side following different amounts of penicillin injections; (3) comparison of the results with the use of hypertonic dextrose solution and distilled
NAKAMURA S, NAGANUMA K. INTRA-ARTERIAL ADMINISTRATION OF PENICILLIN IN TREATMENT OF ACUTE MASTOIDITIS. AMA Arch Otolaryngol. 1955;61(1):61–66. doi:10.1001/archotol.1955.00720020074009
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