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April 1955

Borderline Malignant Lesions of the Larynx

Author Affiliations

From the Department of Laryngology and Broncho-Esophagology, Jefferson Medical College.

AMA Arch Otolaryngol. 1955;61(4):381-385. doi:10.1001/archotol.1955.00720020397001

Borderline malignant lesions of the larynx pose a problem to the physician not only in the selection of treatment but more especially in the diagnosis of their malignant tendencies. It is obvious that if one can detect a premalignant lesion before there is evidence of tissue invasion and metastasis the chances of obtaining a cure are enhanced. However, this diagnosis of premalignancy is extremely difficult both clinically and pathologically. Since we do not know what factors are responsible for malignant degeneration, it cannot be accurately predicted which lesions will become malignant or after what length of time. Certain laryngeal lesions must always be considered as predisposing to malignancy, making it necessary to check them both clinically and histologically over prolonged periods and at frequent intervals. Even so, their management is ofttimes complex and confused. There are four principal laryngeal lesions that should be classified as premalignant: keratosis, carcinoma in situ,