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April 1955

Gonadotropism: An Etiologic Factor in Migraine and Migraine Variants

Author Affiliations

Kansas City, Mo.
From The Department of Otolaryngology, University of Kansas School of Medicine and The Research Clinic.

AMA Arch Otolaryngol. 1955;61(4):401-404. doi:10.1001/archotol.1955.00720020417005

INCIDENCE  In a study of migraine and migraine variants conducted by Grimes and reported by Cecil,1 out of 15,000 persons examined, 1200, or 8%, were affected. No age, social, intellectual, or economic group is immune.Migraine or migraine variants occur more frequently in the female, about 70% of the total.Morton and co-workers2 found that 62% of the crimes perpetrated by women were committed in the premenstrual week.

REASONS FOR THIS INVESTIGATION  Considerable clinical data available strongly suggest that gonadotropism must be considered an etiologic factor in such common conditions as migraine, histaminic cephalgia, tension, and other pain mechanisms due to vasodilation of the cerebral arteries or other vascular dysfunctions.The exact gonadopathy is not clear. I believe, however, that there is frequently both a gonadal imbalance and a deficiency. I further believe that there is more frequently an androgen, rather than estrogen, deficiency in both sexes.In

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