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May 1955

The Nasal and Paranasal Cavities of the Rabbit in Experimental Work

Author Affiliations

From the Department of Otolaryngology, Harvard Medical School, and the Department of Otolaryngology, Massachusetts Eye and Ear Infirmary. Aided by a grant from the William F. Milton Fund, Harvard Medical School, and by United States Public Health Service Grant B-548.

AMA Arch Otolaryngol. 1955;61(5):497-512. doi:10.1001/archotol.1955.00720020514001

In pursuit of the plan to gain more orientation on (1) normal anatomy and histology of the animal in question and (2) pathological conditions occurring "spontaneously" (i. e., in the course of undisturbed life in the animal farm), the rabbit was studied after the rat and the guinea pig (Bibliography) as the third in this series of laboratory animals. In pharmacological experimentation with intranasal ingestion of drugs the rabbit is in general preferred; in work on the basis of olfactory cues, in experimental psychology, the rat is used more frequently.

Knowledge of the status of the individual animals chosen as controls in experiments is of paramount importance. In the formulation of Kubie (1953), "controls depend... upon the meticulous comparison of individuals about each of whom every relevant detail must be known." Hilding (1941) found in apparently healthy rabbits a number with infected sinuses. He advanced the opinion that when a

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