In the treatment of purulent otogenic meningitis, it is extremely important to institute chemotherapy after the complete exenteration of the primary focus of the infection in the temporal bone. A radical mastoidectomy and, if necessary, even a petrosectomy should be performed without hesitation.The present study was undertaken to determine the amount of penicillin necessary to maintain the optimal concentration in the cerebrospinal fluid without at the same time causing any serious side-reactions. Clinical observations were made on seven patients with otogenic meningitis. In addition, 40 rabbits were used in these experiments.The observations made fall into four main categories: (1) the penicillin concentration in the cerebrospinal fluid and blood as a function of time after injection of penicillin by two general methods, extrathecal and intrathecal; (2) a comparison of the amount and duration of penicillin concentration in the cerebrospinal fluid obtained by injection of penicillin by means of
NAKAMURA S, TOYOMURA D, IIDA N. The Treatment of Purulent Otogenic Meningitis. AMA Arch Otolaryngol. 1955;62(1):42–49. doi:10.1001/archotol.1955.03830010044006
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