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August 1955

Effects of Tyzine and Other Vasoconstrictors on Ciliated Epithelium

Author Affiliations

From the Research Laboratories, Chas. Pfizer & Co., Inc.

AMA Arch Otolaryngol. 1955;62(2):154-156. doi:10.1001/archotol.1955.03830020036007

In the study of the effect of certain nasal vasoconstrictors, antihistamines, and antibacterial drugs on ciliated epithelium, Scudi and his colleagues1 reported a parallelism between cellular irritation and loss of ciliary motility. An extrusion of globoid bodies from the surface of the ciliated epithelial cells was also observed after the cessation of ciliary motility. The purpose of the experiments reported here was to compare the effect of tetrahydrozoline (Tyzine), which has recently been reported to be an active vasoconstrictor,2 with those of ephedrine, naphazoline, and phenylephrine on the ciliary movement of mammalian tracheal rings.

It was shown by Mittermaier,3 Buhrmester,4 and others that the pH of nasal secretions varies considerably in various pathological states from alkaline normally and in cases of allergic rhinitis to acid in patients with purulent and mucopurulent discharges. The changes in ciliary motility produced by tetrahydrozoline were, therefore, tested in acid, neutral

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