Since the introduction of antibiotic troches for the treatment of acute and chronic infections of the throat and as a dental prophylaxis after extraction of infected teeth there have been reports of sensitivity of allergic reactions to the local use of these preparations. Penicillin has been the commonest offender, and it has been observed that over 20% of patients treated with penicillin troches have had local tissue reaction to the antibiotic. The clinical evidence of this sensitivity is the redness and swelling of circumvallate papillae at the base of the tongue and a diffuse redness and swelling of the remainder of the tongue, buccal mucous membrane, and soft palate. Troches containing chlortetracycline (Aureomycin) have caused similar reactions. The widespread use of these antibiotics as local medicaments, particularly in allergic persons, may produce a sensitivity which will prevent future parenteral use of that antibiotic should the person need it for a
SILCOX LE. Clinical Evaluation of Diatomic Iodine Therapy in Infections of the Throat. AMA Arch Otolaryngol. 1955;62(3):282–286. doi:https://doi.org/10.1001/archotol.1955.03830030048008
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