As long ago as 1949 it was observed1 that intramuscular or oral administration of the adrenocortical hormones resulted in a beneficial effect on inflamed nasal tissue; however, the use of these hormones in the commonly prescribed doses is accompanied by difficulties of administration and risks of side-effects,* which considerably lessens their value. Recently, several investigators † have reported that an extremely dilute (0.020%) solution of hydrocortisone combined with two vasoconstrictors ‡ is a safe, considerably effective local therapy for ameliorating allergic inflammation and for reducing nasal polyps. The preparation was found to be of less value in treating acute rhinitis, and a very limited investigation4 suggested that the addition of antibiotics to the solution might provide a more effective therapy for inflammations of the nasal mucosa which are caused or accompanied by bacterial infection. Accordingly, the present study was undertaken to determine what value, if any, a topically
PERSKY AH. Hydrocortisone-Antibiotic Therapy in Upper Respiratory Infections. AMA Arch Otolaryngol. 1955;62(4):354–356. doi:10.1001/archotol.1955.03830040008002
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