The maintenance of ventilation and drainage of the maxillary sinus is a wellestablished principle in treatment of infections of this cavity. Since the sulfonamides, penicillin, and other antibiotics have been available, most otolaryngologists use them as supportive therapy during the early stages of the acute infection, while others rely on them for a cure. For the subacute and long-standing acute maxillary sinus infections, the same opinions hold.
Opinions as to the value of antibiotics administered topically within the sinuses are quite varied. Ballenger and Ballenger1 feel that, while concentrations of penicillin greater than 400 units per cubic centimeter inhibit ciliary action in the normal mucosa, instillation of penicillin solutions of 500 to 1000 units per cubic centimeter into the infected maxillary sinus after irrigation is very beneficial. Studies by Fenton and Larsell2 indicate that penicillin in concentrations of 2000 units per cubic centimeter rapidly destroyed streptococci when applied
ELSEN J. The Treatment of Maxillary Sinusitis. AMA Arch Otolaryngol. 1955;62(4):390–392. doi:10.1001/archotol.1955.03830040044007
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