The favorable results obtained with intrabronchial instillation of chemotherapeutic products and antibiotics in the treatment of bronchial suppurations, according to our experience and that of others, led us to infer that in some resistant cases and in tuberculous bronchial lesions continuous administration could be useful.
On surveying the current literature, I read a paper by Mendelbaum, according to which the author instilled isotonic aqueous solutions into the bronchus through a semirigid and radiopaque catheter positioned by the transglottical route amounts up to 300 cc., at the rate of 40 drops per minute. The Process lasted not more than three hours, and the treatment was carried out daily.
Separately, Winternitz and Smith have demonstrated experimentally with dogs that it is possible to introduce 6 liters of isotonic saline solution in two hours by the intrabronchial route, without evidence of macroscopical or microscopical lesions.
The problem in a prolonged bronchial intubation was
MARCHETTI AM. Prolonged Bronchoclysis: Technique. AMA Arch Otolaryngol. 1955;62(5):486–489. doi:10.1001/archotol.1955.03830050028005
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