AMYLOIDOSIS is a condition where there is deposition of a hyaline-like substance, apparently of protein nature but reacting like starch to iodine and sulfuric acid. It commonly involves the mesodermal tissues. It is seen grossly as a structureless translucent material which transmits the color of the underlying tissue and microscopically as a hyaline substance which accumulates between parenchymatous cells and in the connective tissue.
We are reporting a case because of the unusually localized tumor-like nodule found at the base of the tongue. This is in contrast to the usual diffuse nature of amyloidosis, which gives the tongue a uniform enlargement. There is difficulty in the differential diagnosis from other granuloma-like lesions.
Four varieties of amyloidosis are commonly recognized, according to the classification first proposed by Reimann, Koucky, and Eklund.1
1. Secondary amyloidosis is the commonest form and is associated with long-standing infections of destructive nature, such as tuberculosis
CARDWELL EP, BERNHARD WG, AQUINO JA. AMYLOIDOSIS: Report of an Unusual Case. AMA Arch Otolaryngol. 1955;62(5):528–531. doi:https://doi.org/10.1001/archotol.1955.03830050070013
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