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February 1956

Wegeber's Granulomatosis

Author Affiliations

From the Department of Otolaryngology of The Cleveland Clinic Foundation and The Frank E. Bunts Educational Institute.

AMA Arch Otolaryngol. 1956;63(2):120-123. doi:10.1001/archotol.1956.03830080006002

Wegener's granulomatosis is an unusual syndrome that anatomically and pathologically is characterized by necrotizing granulomatous lesions in the respiratory tract, generalized necrotizing angiitis, and glomerulonephritis, and it is of special interest to the otolaryngologist. Several recent articles* give excellent discussions of the syndrome, together with accounts of new and previously reported cases that fulfilled the diagnostic criteria. Klinger,44 in 1931, reported what is now considered to be the first recorded case of the syndrome, and Wegener,† in 1939, reported three cases and postulated the syndrome as being a disease entity. There is disagreement as to what constitutes the entity, i. e., whether nasal lesions are pathognomonic of the entity ‡ or whether involvement of an unspecified part of the respiratory system is distinctive.1

In this paper one case that I believe fits the requirements for the diagnosis of Wegener's syndrome is briefly presented, together with important features