Rhinoscleroma was originally described by von Hebra1 and Kaposi2 between 1870 and 1874. One of these authors claimed, however, to have observed a case in Paris some time previously, which in retrospect, he considered an instance of the same disease. Von Hebra and Kaposi considered the lesion a so-called "granulation sarcoma." Later Geber3 regarded it as a specific granulation of unknown cause. This theory was also championed by Mikulicz,4 who first studied the lesion histopathologically and after whom the characteristic foam cell was named. In 1882 von Frisch isolated a diplobacillus from the nasal secretions and affected tissue, to which he attributed the disease. Koch's postulates, however, have never been satisfied, and this organism is by no means universally accepted as the specific cause of the disease.
In view of the fact that relatively few cases have been reported in the United States, we feel justified
FALKINBURG LW, MacCARDELL FC. ScleromaA Review with Report of a Case. AMA Arch Otolaryngol. 1956;64(3):190–195. doi:10.1001/archotol.1956.03830150020004
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: