Javid and Settlage1 in 1956 discussed the use and efficacy of urea, intravenously, for the purpose of reducing cerebrospinal fluid pressure, and suggested the possible value of the use of urea in Ménière's disease and various intracranial conditions. In this respect, therefore, I wish to bring attention to a report by Brown,2 in 1943, who accidentally discovered the curative effect of urea, following a urea-concentration test, in a patient who had suffered severe headaches of a migrainous nature for several years and who was hospitalized for investigation with a view to operation for cerebral compression for relief of his headaches. Upon continuation of 20 grains (1.3 gm.) of urea daily the headaches did not return, and the patient remained free from his migraine for nine years, except during periods when he gave up the regular use of urea. Brown reports three other cases of migraine with marked relief.
MUSKAT I. UREA IN MÉNIÈRE'S DISEASE, MIGRAINE, AND ALLIED CONDITIONS: Preliminary Report. AMA Arch Otolaryngol. 1956;64(3):241–242. doi:10.1001/archotol.1956.03830150071013
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