The low incidence of hearing loss resulting from the administration of streptomycin hydrosulfate in the treatment of pulmonary and other forms of tuberculosis has been previously reported.* These reports covered patients who were under treatment at Veterans Administration tuberculosis facilities and other institutions for the treatment of tuberculosis. The period of observation varied from 42 days2 to 8 months.†
In recent years the treatment of non-surgical pulmonary tuberculosis has been shifting from hospital and sanitarium care to home care with periodic check-ups in out-patient clinics. Because of the high incidence rate of relapse in "arrested" cases of tuberculosis of the lung prior to chemotherapy and the low incidence of relapse of those patients who continue indefinitely on chemotherapy after discharge from the hospital, Dooneief, Hite, and Bloch ‡ advocated "chemotherapy under close observation should be prolonged indefinitely except in the presence of threatening side effects or until
WITCHELL IS. The Prolonged Administration of Streptomycin Hydrosulfate: The Effect on Hearing. AMA Arch Otolaryngol. 1956;64(6):514–519. doi:10.1001/archotol.1956.03830180064009
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